Antibacterial Hydrogel Coating Protection for Implanted Biomaterials

Implanted biomaterials may get colonized by bacteria during surgery...


Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.


Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.

VIDEO of biofilm formation


An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.

Antibacterial coatings classification


DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. 



Risultati immagini per dac hydrogel


Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)





Mechanism of Implant-Related Infection

  DAC Barrier Effect

Surgical Technique



Scientific Background


 Eur J Orthop Traumatol 2021

DAC®  Antibacterial Hydrogel Coating for Megaprosthesis


 Frontiers in Medicine 2020  

The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel 


 Hip International 2020 

Antibiotic-loaded Hydrogel Coated Revision Hip Prosthesis 


Journal of Bone and Joint Infection 2020 

Antimicrobial Coated Orthopaedic Implants Efficacy: a Systematic Review and Meta-Analysis


 ClinicalTrials 2020 

Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery 


Microorganisms 2020

Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery


ECM 2020 

Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits


Muscles, Ligaments and Tendons Journal 2020

Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study


Bone & Joint Research 2019

Antibacterial coating of implants: are we missing something? 


Eur Rev 2019

Orthopaedic oncology and antibacterial coatings


Maitrise Orthopedique Journal 2019

Surgical Technique and Clinical Applications (see full text below)


JOA 2018

Cost-benefit balance of DAC and other antibacterial coatings 


Dr. Willemijn Boot - PhD thesis 2018 

Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands


 Int Orthop 2018

Two-stage hip revision with DAC coating provides better results than without


 Hydrogels 2018

Hydrogel coating: from basic research to clinical applications


KSSTA 2018

Clinical application to one-stage revision of PJI


Orthop Proceedings 2018

Clinical application to two-stage hip revision of PJI


Antibacterial Coating of Implants in Ortho-Trauma - Springer Ed. 2018


 JORT 2017

 Clinical application to osteosynthesis and fracture fixation devices 


JBJI 2017

 Anti-adhesive and anti-bacterial effects of hyaluronic acid


CORR 2017

No interference of antibiotic-looaded hydrogel with bone healing in the animal model


 BJJ 2017-2 


BJJ 2017-1




Chapter 9. Infection after Joint Arthroplasy - Thieme Ed. 2017

 by A. Chen, CL Romanò, L Drago, J Parvizi


JBJI 2016

Clinical application to joint prosthesis


 BJJ 2016-1


BJJ 2016-2


Med Inflamm 2016


 Copertina anteriore 

Paradigm change in antibacterial coatings - Springer Ed. 2016


JOSR 2015

Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal


 Orthop Today 2015


CORR 2015


BJJ 2015 

The Management of Periprosthetic Infections in the Future


eCM 2015


BJJ 2014 


CORR 2014 


Int Orthop 2014


Copertina anteriore

Biomaterials for Medicine - Universitas Studiorum Ed. 2014


MSIS 2013 


Int J Pharm 2013


 BJJ 2011 



Surgical Tips on Maitrise Orthopedique 2019:

A Barrier Against Implant-Related Infections

Risultati immagini per dac hydrogel


Clinical Indications

DAC is a CE marked medical device, specifically designed to protect implanted biomaterials from bacterial adhesion and colonization, in order to reduce or prevent the occurrence of post-surgical infections.

The device can be used to protect cementless and hybrid (partially cemented) joint prosthesis (hip, knee, shoulder, etc.), fracture fixation devices (plates, nails, screws, etc.), dental implants, etc..

All patients may take advantage from the antibacterial protection offered by DAC hydrogel, that is especially useful for those patients at higher risk for infection (e.g.: old-aged patients, diabetic and/or obese, smokers, alcohol or drug abusers, immunocompromised hosts, malnurished or oncological patients, etc.) and/or undergoing high risk procedures (revision or tumor surgery, contaminated procedures, etc.).


For more information on DAC technology: 


Download the 2019 White Paper

WP2019 WP2019 [1.854 Kb]

D.A.C.: The Result of an International Collaborative Project

DAC is the result of a international project, funded by the European Community under the 7th Framework Programme, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs.

To learn more, visit the official website of  iDAC Project