The New Antibacterial Hydrogel Coating to Protect Prosthesis and Biomaterials

Implanted biomaterials may get colonized by bacteria during surgery...


Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.


Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.


Look at a VIDEO of biofilm formation


An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.

Antibacterial coatings classification


DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. 



Risultati immagini per dac hydrogel




Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)





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Mechanism of Implant-Related Infection

  DAC Barrier Effect

Surgical Technique



Visit also [English]




 Scientific publications:



ClinicalTrials 2020: Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery for Secondary Prevention of Complex Chronic Periprosthetic Hip Joint Infection



Microorganisms 2020: Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery


ECM 2020: Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits



Muscles, Ligaments and Tendons Journal 2020: Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study


Bone & Joint Research 2019: Antibacterial coating of implants: are we missing something? 


Eur Rev 2019: Orthopaedic oncology and antibacterial coatings


JOA 2018 : Cost-benefit balance of DAC and other antibacterial coatings 


Dr. Willemijn Boot PhD thesis, 2018 - Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands


 Int Orthop 2018: Two-stage hip revision with DAC coating provides better results than without


 Hydrogels 2018: Hydrogel coating: from basic research to clinical applications


KSSTA 2018: Clinical application to one-stage revision of PJI


Orthop Proceedings 2018: Clinical application to two-stage hip revision of PJI


 JORT 2017 : Clinical application to osteosynthesis and fracture fixation devices 


JBJI 2017 : Anti-adhesive and anti-bacterial effects of hyaluronic acid


CORR 2017 : No interference with bone healing in the animal model


Antibacterial Coating of Implants in Orthopaedics and Trauma 2017



 BJJ 2017-2 


BJJ 2017-1


JBJI 2016 : Clinical application to joint prosthesis



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Paradigm change in antibacterial coatings - Springer Ed. 2016


BJJ 2016-2 - BJJ 2016-1


Med Inflamm 2016


JOSR 2015: Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal in an Evolving Panorama



Orthop Today 2015


CORR 2015


BJJ 2015


eCM 2015 (University Medical Center Utrecht, Utrecht, The Netherlands)


BJJ 2015 (see below for full text)


BJJ 2014 


CORR 2014 


Int Orthop 2014


MSIS 2013 


Int J Pharm 2013


 BJJ 2011


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Biomaterials for Medicine


Chapter 9. Infection after Joint Arthroplasy

by A. Chen, CL Romanò, L Drago, J Parvizi



The New Antibacterial Hydrogel Coating to Protect Prosthesis and Biomaterials - DAC Implant Coating Protection
George et al 2015 George et al 2015 [1.923 Kb]

DAC is the result of a European funded project, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs. To learn more, visit the official website of the iDAC Project 



A Barrier Against Infection



Risultati immagini per dac hydrogel


Clinical Indications:

DAC is a CE marked medical device, specifically designed to protect implanted biomaterials from bacterial adhesion and colonization, in order to reduce or prevent the occurrence of post-surgical infections.

The device can be used to protect cementless and hybrid (partially cemented) joint prosthesis (hip, knee, shoulder, etc.), fracture fixation devices (plates, nails, screws, etc.), dental implants, etc..

All patients may take advantage from the antibacterial protection offered by DAC hydrogel, that is especially useful for those patients at higher risk for infection (e.g.: old-aged patients, diabetic and/or obese, smokers, alcohol or drug abusers, immunocompromised hosts, malnurished or oncological patients, etc.) and/or undergoing high risk procedures (revision or tumor surgery, contaminated procedures, etc.).


For more information on DAC technology: