The New Antibacterial Hydrogel Coating to Protect Prosthesis and Biomaterials

Implanted biomaterials may get colonized by bacteria during surgery...


Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.


Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.


Look at a VIDEO of biofilm formation


An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.

Antibacterial coatings classification


DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. 



Risultati immagini per dac hydrogel




Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)





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Mechanism of Implant-Related Infection

 What is DAC 

 DAC Barrier Effect

Surgical Technique

Presentations on VUMEDI

(for professionals only)

Part 1

Part 2

One-Stage Exchange



Visit also



 Scientific publications:


Peri-prosthetic Joint Infection (PJI) has a tremendous social and economic impact in Europe and worldwide.


DAC is highly cost-effective when used to prevent septic complications in joint replacement.

JOA 2018 : Cost-benefit balance of DAC and other antibacterial coatings



Risultati immagini per romanò drago kuhn pji


 Chapter 9: Antibacterial Coating of Implants in Orthopaedics and Trauma


 Int Orthop 2018: Two-stage hip revision with DAC coating provides better results than without

 Hydrogels IntechOpen 2018: Hydrogel coating: from basic research to clinical applications

KSSTA 2018: Clinical application to one-stage revision of PJI

Orthop Proceedings 2018: Clinical application to two-stage hip revision of PJI

 JORT 2017 : Clinical application to osteosynthesis and fracture fixation devices 

JBJI 2017 : Anti-adhesive and anti-bacterial effects of hyaluronic acid

CORR 2017 : No interference with bone healing in the animal model

 BJJ 2017-2 - BJJ 2017-1

JBJI 2016 : Clinical application to joint prosthesis



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Paradigm change in antibacterial coatings - Springer Ed. 2016


BJJ 2016-2 - BJJ 2016-1

Med Inflamm 2016

Orthop Today 2015

CORR 2015

BJJ 2015

eCM 2015 (University Medical Center Utrecht, Utrecht, The Netherlands)

BJJ 2015 (see below for full text)

BJJ 2014 - CORR 2014 - Int Orthop 2014

MSIS 2013 - Int J Pharm 2013 - BJJ 2011

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Biomaterials for Medicine


Chapter 9. Infection after Joint Arthroplasy

by A. Chen, CL Romanò, L Drago, J Parvizi



The New Antibacterial Hydrogel Coating to Protect Prosthesis and Biomaterials - DAC Implant Coating Protection
George et al 2015 George et al 2015 [1.923 Kb]

The Galeazzi Institute in Milano, Italy, is among the leaders of a European Project, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs. To learn more, visit the official website of the iDAC Project and Galeazzi.




Follow DAC technology developments, to be presented at the next Milano Biofilm Meeting:

 MBM 2017

 MBM 2015

 MBM 2013


and in many other important venues...

.... and Venues

ECTES 2017, Bucarest, RO

EFORT 2017 - Vienna, A

EBJIS 2017 - Nantes, F

 IDSA 2017 - San Diego, USA

 SIOT 2017 - Palermo, I

 SOFCOT 2017 - Paris, F

  SICOT 2017 - Cape Town, RSA


A Barrier Against Infection



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Clinical Indications:

DAC is a CE marked medical device, specifically designed to protect implanted biomaterials from bacterial adhesion and colonization, in order to reduce or prevent the occurrence of post-surgical infections.

The device can be used to protect cementless and hybrid (partially cemented) joint prosthesis (hip, knee, shoulder, etc.), fracture fixation devices (plates, nails, screws, etc.), dental implants, etc..

All patients may take advantage from the antibacterial protection offered by DAC hydrogel, that is especially useful for those patients at higher risk for infection (e.g.: old-aged patients, diabetic and/or obese, smokers, alcohol or drug abusers, immunocompromised hosts, malnurished or oncological patients, etc.) and/or undergoing high risk procedures (revision or tumor surgery, contaminated procedures, etc.).


To calculate the risk of peri-prosthetic joint infection (PJI), visit the AppStore or GooglePlay and freely download the PJI Risk app


Risultati immagini per pji risk



For more information on DAC technology:


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